Charlie Bradford, an unemployed filmmaker, is doing the best he can to both distance himself from the chaos of his childhood home and make sense out of a complicated relationship with his roommate. But his eccentric mother Linda, a compulsive hoarder who suffers from depression and manic consumption, has a tendency to keep the people and things she loves close at hand. Charlie’s sister Lisa has become a home health care aide to the sick and dying after a series of arrests for bad checks and shoplifting. Also, Charlie’s younger sister Penny is trying to overcome her agonizing shyness by starting a career as a home stager. When a water stain on their garage door is interpreted as an apparition of the Blessed Virgin, the house attracts the unwanted attention of the county health department, which gives the Bradfords a week to clean up their act or lose their home.